Clomid, sometimes referred to as Clomiphene, is a medication for stimulating ovulation. Clomid is a fertility drug prescribed to induce ovulation. Actually, Clomid stimulates female ovaries to produce more follicles every month. Clomid increases mature follicles quantity in the ovaries, thus providing the possibility of ovulation and pregnancy. Clomid is prescribed for women with hormone deficiency. They are not able to produce follicles and release ovum in ovulation. Clomid produces the hormones to help a woman to get pregnant. Clomid is an estrogen receptor modulator, increases gonadotropins by inhibiting negative respond in the hypothalamus.
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Nolvadex is a Selective Estrogen Receptor Modulator, an anti-estrogen receptor in breast fibrous tissue. It is indicated in the standard anti-estrogen treatment for hormone-positive breast cancer at the early stage. In addition, aromatase inhibitors are indicated to stop the production of estrogen in post-menopausal period in women. Certain breast cancer cells need estrogen to develop. Estrogen activates the estrogen receptor in these breast cancer cells. Nolvadex helps to bind them to the estrogen receptor without activating. Then estrogen is prevented from binding to its receptor. Thus breast cancer cell development is blocked.
Clomid is an inhibitor to induce an ovulation. Clomid works in the hypothalamus where it competes for estrogen. When these binding sites are occupied by Clomid, the hypothalamus produces more gonadotropin-releasing hormone stimulating the hypophysis to produce Follicle-stimulating hormone. The active component Clomiphene is known at the US market as Clomid manufactured by Aventis Laboratories and as Serophene manufactured by Serono Laboratories.
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